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Brenner: Pharmacology, 3rd Edition
Chapter 02: Pharmacokinetics
1. A patient with renal disease exhibits zero-order elimination of a drug she is taking. Which description of the drug’s elimination half-life is correct?
A. directly proportional to the drug’s clearance
B. inversely proportional to the drug’s volume of distribution
C. directly proportional to the plasma drug concentration
D. inversely proportional to the dose administered
E. varies with the route of drug administration
ANS: C. directly proportional to the plasma drug concentration
2. A drug with a first-order elimination rate constant of 0.23 L/hour is administered by continuous intravenous infusion. About how long will it take to achieve a steady-state plasma drug concentration?
A. 5 hours
B. 10 hours
C. 15 hours
D. 30 hours
E. 50 hours
ANS: C. 15 hours
3. Which description best characterizes drug metabolism involving conjugation of a drug with glucuronate?
A. reduces the rate of biliary drug excretion
B. increases the rate of renal drug excretion
C. typically increases the pharmacologic activity of the drug
D. primarily occurs in the smooth endoplasmic reticulum
E. often induced or inhibited by other drugs
ANS: B. increases the rate of renal drug excretion
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